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Scientists Develop ‘Superdrug’ To Cure Diabetes

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Scientists have created a new drug cocktail that can induce insulin-producing cells to regenerate at a rate that is fast enough to work in human treatments.

This is a key step in the pursuit of a cure for diabetes that restores the body’s ability to make insulin.

The recent study by researchers at the Icahn School of Medicine at Mount Sinai in New York City, NY, reveals how a novel combination of two classes of drug can make adult human beta cells replicate at a rate of 5–8 percent per day.

The team reports the findings in a paper that features in the journal Cell Metabolism.

“We are very excited about this new observation,” says lead author Dr. Andrew F. Stewart, who is director of the Mount Sinai Diabetes, Obesity, and Metabolism Institute, “because, for the first time, we are able to see rates of human cell beta cell replication that are sufficient to replenish beta cell mass in human beings.”

In earlier work, the team had investigated a small molecule that blocks an enzyme called dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). This molecule led to a beta cell proliferation rate of 1.5 to 3 percent.

In the new study, the team demonstrated how adding a small molecule from a different class of drug raised the proliferation rate to an average of 5–8 percent. The second drug blocks members of the transforming growth factor beta superfamily (TGFβSF).

However, while the study has taken an important step by showing that the drug combination can regenerate beta cells fast enough for treatment, there is still some work to do.

As Dr. Stewart explains, “The next big hurdle is figuring out how to deliver them directly to the pancreas.”

Diabetes is a disease in which blood glucose rises to harmful levels. Persistent high blood glucose damages blood vessels, nerves, and other body systems. It can lead to vision loss, kidney disease, and heart problems.

Blood glucose levels rise because of difficulties with producing and using insulin, a hormone that helps the body’s cells absorb and use glucose to make energy.

According to the World Health Organisation, estimates suggest that there could be as many as 300 million people worldwide with diabetes by 2025.

There are two main types of diabetes: type 1 and type 2. Around 90–95 percent of adults with diabetes have type 2.

In type 1 diabetes, the lack of control of blood glucose occurs because the immune system destroys insulin-producing beta cells in the pancreas.

Type 2 diabetes usually starts with insulin resistance, a condition in which cells become less effective at using insulin. The pancreas initially compensates by making more insulin, but this is not a long-term solution, and blood glucose levels eventually climb.

Although the two types have differences, recent studies reveal that type 1 and type 2 diabetes share a major feature: a diminished supply of functioning insulin-producing beta cells.

Health

Rainy Season: LAWMA Completes Rehabilitation of Olusosun Dumpsite

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…calls for responsible waste disposal

AJAGBE ADEYEMI TESLIM

SPONSORED BY: H&H

As the rains approach, the Lagos Waste Management Authority (LAWMA) has completed the rehabilitation of Olusosun dumpsite, to ensure smooth waste disposal operations across the state.

Managing Director/CEO of LAWMA, Dr. Muyiwa Gbadegesin, who made this known in a statement on Thursday, said the maintenance effort was aimed at improving operational efficiency in anticipation of the rainy season.

He said, “Our primary objective in rehabilitating Olusosun dumpsite is to ensure that waste disposal trucks can navigate through the dumpsite seamlessly, even in adverse weather conditions, especially during heavy rainfall when logistical challenges tend to arise”.

Dr. Gbadegesin stated that, in addition to the recently completed maintenance efforts, LAWMA was focused on enhancing operational efficiency to improve turnaround times for waste disposal trucks, adding that the rehabilitation would significantly reduce queue times, translating to faster and more effective waste collection services.

“Our commitment to environmental sustainability extends beyond operational enhancements. We urge residents to join us in prioritising responsible waste disposal practices to safeguard our environment”, he stressed.

The LAWMA boss further highlighted the importance of proper waste disposal, urging residents to avoid dumping waste in drains, especially during the rainy season, known for disrupting the drainage system and posing serious environmental risks to lives and properties.

“We encourage residents to patronise accredited Private Sector Participation (PSP) operators for their waste disposal needs. By supporting licensed operators, individuals contribute to a cleaner and healthier environment for all”, he reiterated.

The Managing Director emphasised the importance of residents familiarising themselves with their PSPs, who play a vital role in waste management at the local level, adding that, by understanding and engaging with their designated PSP operators, residents could ensure efficient and effective waste disposal services in their communities.

“We are committed to facilitating this process by publishing detailed PSP contacts for all areas in the state. This initiative aims to empower residents to take ownership of waste management practices in their neighborhoods, ultimately contributing to a cleaner and healthier environment for all”, he assured.

For more information about LAWMA’s initiatives and how to support efforts to maintain a clean environment, please visit www.lawma.gov.ng or call our toll-free numbers: 080000LAWMA (08000052962), 07080601020 and 617.

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Entertainment

Singer, Okiki Bright Speaks on “Ambition” Album, Industry Struggles in New Explosive Interview

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AJAGBE ADEYEMI TESLIM

SPONSORED BY: H&H

on the 6th of November, 2023, Nigerian Fuji musician Okiki Bright released his much-anticipated album, “Ambition.” Distributed and marketed by Role Model Entertainment, this album marks a significant milestone in Okiki Bright’s career, and it’s already making waves in the music industry. Today, the artist took to the airwaves at Fresh FM in Ibadan for an exclusive interview hosted by Alhaji Saheed Babatunde, where he delved into the various aspects of the album and shared insights on the challenges within the music industry.

“Ambition” on All Streaming Platforms
Before diving into the interview details, it’s worth noting that “Ambition” is now available on all major streaming platforms. Listeners can enjoy the fusion of indigenous Fuji rhythms with contemporary melodies that Okiki Bright brings to life through this album. The music promises to be a captivating auditory experience, staying true to the didactic traditions of the genre while embracing innovation.

Insights from the Interview
During the interview at Fresh FM, Okiki Bright opened up about his journey, the inspiration behind “Ambition,” and the struggles he’s faced in the music industry. He discussed how his music is a bridge between tradition and modernity, much like his mentor, Chief Adewale Ayuba. The artist emphasized the importance of cultural narratives and morals in his compositions and how they are presented on danceable modern rhythms, creating not just music but a cultural experience for his audience.

The interview shed light on the enduring power of mentorship in the music industry and the coexistence of diverse musical styles, carrying on the torch lit by legends like Dr. Sikiru Ayinde Barrister. Okiki Bright’s journey and his latest album exemplify the fusion of tradition and ambition within the rich tapestry of Nigerian music.

As “Ambition” continues to gain traction on streaming platforms, music enthusiasts can immerse themselves in the cultural and musical experience that Okiki Bright brings to life. The interview at Fresh FM not only provided insights into the album but also underscored the artist’s dedication to preserving the rich heritage of Fuji music while pushing the boundaries of innovation.

Stay tuned for more updates on Okiki Bright’s musical journey and the ongoing success of “Ambition,” as it leaves an indelible mark on the Nigerian music scene.

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Health

LAWMA Organises Medical Checks For Sweepers

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AJAGBE ADEYEMI TESLIM

SPONSORED BY: H&H

The Lagos Waste Management Authority (LAWMA) has organised a free medical screening, for over 1000 sanitation workers (street sweepers) August24news.com has learnt.

The event took place at the Authority’s headquarters, Ijora Olopa. Lagos.

Speaking at the event, the Acting Managing Director of LAWMA, Mr. Kunle Adebiyi, noted that the exercise was a testament to the commitment of Governor Babajide Sanwo-Olu’s administration, to prioritise the wellness of LAWMA sweepers.

He said, “Your well-being is our priority. Whatever happens to your health, will affect us in one way or the other. Therefore, we don’t want
any ill-health to befall you.

Today, your blood pressure, sugar level, urine and eye and hepatitis will be checked for proper diagnosis.

The aim of this is to manage the health of our workers and detect early health issues.

Our sweepers are our heroes, we need to take good care of them. We have over 16,000 of them who keep Lagos clean everyday. Our aim is to ensure we capture all of them in this screening exercise and there will be follow ps.

Some will be administered for consultation, some will be for referral, some will be given medications. All of these is to ensure their health is properly managed.

We appreciate the Governor for his
consistent support”.

The Medical Director of LAWMA, Dr. (Mrs.) Modupe Okoh, noted that the medical screening exercise was a demonstration of the state’s commitment to the welfare of LAWMA’s workforce, adding that early detection of
diseases would go a long way in helping to manage the health of sweepers who work tirelessly.

One of the beneficiaries, Nafisat Rahman, appreciated the state government for the medical checks.  In her words: “We do spend a lot on hospital bills, but with this kind of initiative, it will reduce it and we will be more aware of our health status. I want them to continue with this kind of exercise”, she said.

Another beneficiary, Godwin Imeh, said the medical screening exercise was a nice initiative. He encouraged the Authority to continue to
prioritise the welfare of sweepers.

In attendance at the event were members of LAWMA’s management staff.

The medical outreach for LAWMA’s sanitation workers is a continuous exercise, with sweepers in other districts in the state set to benefit from the health screening.

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