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Scientists Develop ‘Superdrug’ To Cure Diabetes

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Scientists have created a new drug cocktail that can induce insulin-producing cells to regenerate at a rate that is fast enough to work in human treatments.

This is a key step in the pursuit of a cure for diabetes that restores the body’s ability to make insulin.

The recent study by researchers at the Icahn School of Medicine at Mount Sinai in New York City, NY, reveals how a novel combination of two classes of drug can make adult human beta cells replicate at a rate of 5–8 percent per day.

The team reports the findings in a paper that features in the journal Cell Metabolism.

“We are very excited about this new observation,” says lead author Dr. Andrew F. Stewart, who is director of the Mount Sinai Diabetes, Obesity, and Metabolism Institute, “because, for the first time, we are able to see rates of human cell beta cell replication that are sufficient to replenish beta cell mass in human beings.”

In earlier work, the team had investigated a small molecule that blocks an enzyme called dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). This molecule led to a beta cell proliferation rate of 1.5 to 3 percent.

In the new study, the team demonstrated how adding a small molecule from a different class of drug raised the proliferation rate to an average of 5–8 percent. The second drug blocks members of the transforming growth factor beta superfamily (TGFβSF).

However, while the study has taken an important step by showing that the drug combination can regenerate beta cells fast enough for treatment, there is still some work to do.

As Dr. Stewart explains, “The next big hurdle is figuring out how to deliver them directly to the pancreas.”

Diabetes is a disease in which blood glucose rises to harmful levels. Persistent high blood glucose damages blood vessels, nerves, and other body systems. It can lead to vision loss, kidney disease, and heart problems.

Blood glucose levels rise because of difficulties with producing and using insulin, a hormone that helps the body’s cells absorb and use glucose to make energy.

According to the World Health Organisation, estimates suggest that there could be as many as 300 million people worldwide with diabetes by 2025.

There are two main types of diabetes: type 1 and type 2. Around 90–95 percent of adults with diabetes have type 2.

In type 1 diabetes, the lack of control of blood glucose occurs because the immune system destroys insulin-producing beta cells in the pancreas.

Type 2 diabetes usually starts with insulin resistance, a condition in which cells become less effective at using insulin. The pancreas initially compensates by making more insulin, but this is not a long-term solution, and blood glucose levels eventually climb.

Although the two types have differences, recent studies reveal that type 1 and type 2 diabetes share a major feature: a diminished supply of functioning insulin-producing beta cells.

Health

Africa CDC Congratulates Democratic Republic of the Congo on Launching Mpox Vaccination Campaign

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AJAGBE ADEYEMI TESLIM

Africa Centres for Disease Control and Prevention (Africa CDC) congratulates the Democratic Republic of the Congo (DRC) on the successful launch of its Mpox vaccination campaign in two high-priority provinces.

This marks a critical milestone in the ongoing efforts to control the Mpox outbreak and safeguard vulnerable populations across the country.


In collaboration with the DRC’s Ministry of Public Health and Prevention, Africa CDC, along with its global partners, including European Union / HERA, United States Government, World Health Organization (WHO), UNICEF, Gavi, and the World Food Programme (WFP) is supporting the vaccination of key at-risk groups in Equateur and North Kivu provinces. The campaign will soon expand to additional provinces to ensure more comprehensive coverage.


The arrival of 265,000 doses of the MVA-BN Mpox vaccines, generously donated by the European Union and facilitated by Africa CDC in collaboration with Bavarian Nordic, the Government of the United States, and Gavi, is a significant step toward improving the country’s capacity to manage the outbreak. Africa CDC applauds this collaboration, which underscores the collective global commitment to tackling Mpox in Africa.


“Africa CDC commends the DRC’s swift action in launching the vaccination campaign, which showcases the strength of its public health leadership. By prioritizing vulnerable populations, including frontline health workers and those most at risk, the country is taking critical steps to contain the outbreak. Africa CDC remains committed to working closely with the DRC to ensure vaccines reach those who need them the most, while also working to strengthen health systems to prevent future outbreaks. Our top priority is to secure safe and effective vaccines for children in the next phase of vaccination,” said Africa CDC Director General, H.E. Dr. Jean Kaseya.


Mpox continues to pose a serious threat, particularly to vulnerable groups such as children, individuals with compromised immune systems, and those living in areas with limited healthcare access. The Continental Incident Management Support Team (IMST) has been actively engaged in supporting the DRC’s response efforts by providing technical expertise, coordinating vaccine deployment, and offering logistical assistance to ensure effective distribution across affected regions.


Africa CDC also recognizes the crucial role of infection prevention and control measures, community engagement, and public awareness campaigns in curbing the spread of Mpox. These efforts, alongside vaccination, are essential in protecting populations and minimizing the impact of the outbreak.

As part of its commitment to the fight against Mpox, Africa CDC will continue to support DRC and all 16 other affected countries’ response through technical assistance, capacity-building, and coordination with international partners. The vaccination campaign serves as a critical tool in safeguarding public health, and Africa CDC looks forward to further collaborative efforts to protect communities and strengthen Africa’s resilience against future public health threats.

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Africa CDC congratulates Japan and DRC on the Signing of Notes for a donation of Mpox Vaccines

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AJAGBE ADEYEMI TESLIM

Africa CDC congratulates the Government of Japan and the Government of the Democratic Republic of the Congo (DRC) on the agreement to donate Lc16 Mpox vaccines, along with specialized inoculation needles.

A signing ceremony in Kinshasa formalized the exchange of notes for this crucial grant, marking a significant milestone in the cooperation between the two governments.

This donation comes at a pivotal time as the DRC continues to battle a regional Mpox outbreak, with cases rising significantly since November 2023. Japan’s contribution is a crucial boost as the Mpox vaccine is the only shot currently approved for children.

Mpox has been endemic in several African countries for decades. On 13 August 2024, the Africa Centres for Disease Control and Prevention (Africa CDC) declared Mpox a Public Health Emergency of Continental Security (PHECS). This declaration prompted a more coordinated international response. Vaccination is one part of a comprehensive response, including surveillance, case detection, clinical care, infection prevention and control, and risk communication and community engagement. The challenges in responding can quickly be exacerbated if Africa has limited access to critical countermeasures such as vaccines and diagnostics.

The outbreak has disproportionately affected vulnerable populations, with children accounting for 60% of cases and people living with HIV/AIDS experiencing the most severe outcomes. Given these challenges, Africa CDC has called for a united and coordinated response to address the crisis.

H.E. Dr. Jean Kaseya, Director General of Africa CDC, expressed his gratitude for Japan’s support, stating:
“I am deeply appreciative of Japan’s generous donation of Lc16 Mpox vaccines and specialized vaccination needles to the Democratic Republic of the Congo. This timely assistance will significantly bolster our ongoing efforts to contain the outbreak, and I am confident that this partnership will help mitigate the public health threat posed by Mpox, not only in the DRC but across the continent.”

The Senior Deputy Minister for Foreign Affairs of Japan, Takeshi Akahori, added:
“We are aware that the number of infection cases continues to rise in the DRC and other countries, and we are monitoring the situation closely in coordination with the WHO. I hope that these vaccines and needles will contribute meaningfully to the fight against Mpox.”

Japan remains committed to supporting the DRC in its fight against this public health threat, working closely with Africa CDC, the World Health Organization (WHO), and other global health partners.

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Rainy Season: LAWMA Completes Rehabilitation of Olusosun Dumpsite

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…calls for responsible waste disposal

AJAGBE ADEYEMI TESLIM

SPONSORED BY: H&H

As the rains approach, the Lagos Waste Management Authority (LAWMA) has completed the rehabilitation of Olusosun dumpsite, to ensure smooth waste disposal operations across the state.

Managing Director/CEO of LAWMA, Dr. Muyiwa Gbadegesin, who made this known in a statement on Thursday, said the maintenance effort was aimed at improving operational efficiency in anticipation of the rainy season.

He said, “Our primary objective in rehabilitating Olusosun dumpsite is to ensure that waste disposal trucks can navigate through the dumpsite seamlessly, even in adverse weather conditions, especially during heavy rainfall when logistical challenges tend to arise”.

Dr. Gbadegesin stated that, in addition to the recently completed maintenance efforts, LAWMA was focused on enhancing operational efficiency to improve turnaround times for waste disposal trucks, adding that the rehabilitation would significantly reduce queue times, translating to faster and more effective waste collection services.

“Our commitment to environmental sustainability extends beyond operational enhancements. We urge residents to join us in prioritising responsible waste disposal practices to safeguard our environment”, he stressed.

The LAWMA boss further highlighted the importance of proper waste disposal, urging residents to avoid dumping waste in drains, especially during the rainy season, known for disrupting the drainage system and posing serious environmental risks to lives and properties.

“We encourage residents to patronise accredited Private Sector Participation (PSP) operators for their waste disposal needs. By supporting licensed operators, individuals contribute to a cleaner and healthier environment for all”, he reiterated.

The Managing Director emphasised the importance of residents familiarising themselves with their PSPs, who play a vital role in waste management at the local level, adding that, by understanding and engaging with their designated PSP operators, residents could ensure efficient and effective waste disposal services in their communities.

“We are committed to facilitating this process by publishing detailed PSP contacts for all areas in the state. This initiative aims to empower residents to take ownership of waste management practices in their neighborhoods, ultimately contributing to a cleaner and healthier environment for all”, he assured.

For more information about LAWMA’s initiatives and how to support efforts to maintain a clean environment, please visit www.lawma.gov.ng or call our toll-free numbers: 080000LAWMA (08000052962), 07080601020 and 617.

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